Links for your consideration

Here are a few things I've come across in the past couple of weeks that might be of interest and just maybe you might not have come across already.

Links and interesting bits

Despite my insistence in the last post that I would have a new post up within two weeks- here we are a month later and still not even a hint of a deep brain stimulation post! I'm starting to realise that trying to balance blogging with any semblance of regularity, numerous PhD commitments and life in general isn’t exactly easy. So after finally coming to that realisation I’ve decided my best bet is to start making more regular but smaller posts, maybe giving a quick summary of some interesting recent research or pointing you in the direction of any interesting science-y related article out there in cyber space. That way I can take a bit more time over the longer posts without feeling under pressure and hopefully as I gain a bit more confidence and competence with this writing lark I can make the bigger topic driven posts more frequent!

So here are a few things that have caught my eye online in the past few weeks……

The Centre Surround model and Disorders of the Basal Ganglia

Hello! after a break that was far too long I'm back to the blogging (those first two posts obviously took it out of me!). Hopefully I can pick up a bit of momentum this time round and manage a few more in quick succession. For this post I want to follow on from the first I did about the Basal Ganglia, in particular let's talk about how the centre surround model I introduced in the first post has helped clinical scientists in understanding what causes lie behind symptoms they observe in patients with a range of high profile disorders of the Basal Ganglia. I'll be taking my first post as a start point and building on that because I want to avoid any returning readers (wishful thinking?) from having to read the same things twice (plus I'm lazy and don't want to type the same thing multiple times) so now would be a good time to go back now and have a look here.

Brainy names

This is just a mini post to pass the time before I get around to writing the next one..

Here are a couple of links to two really cool posts on the Neuroskeptic blog, definitely my favourite blog and one which anybody with an interest in neuroscience and psychology should know about.

Post 1

Post 2

The posts contain cross sections of the human brain with different structures labelled with their scientific (usually latin, sometimes greek) names alongside the literal translations of those names- "etymological maps" of the brain. This prevalence of Latin names for brain structures is a hangover from the tradition beginning centuries ago that in some cases even stretched to the beginning of the 20th century where Latin was the accepted language for medical terminology. Consequently, to the unititated learning about brain anatomy can be quite intimidating or worse still people might completely switch off when they're met with a wall of unintelligible jargon.

Action selection and the Basal Ganglia

What is action selection and how could the brain do it?

For my first full post I thought that rather then pick out some recent paper that’s made a big splash or something prominent in the media I would just talk about a topic in neuroscience I find interesting, it isn’t even related to what I study for my PhD, just something I find interesting and hopefully you will to. I’m going to talk about the action selection: what it is and how it's carried out in the brain. To put it simply as we engage with the world around us any number of potential actions are possible and action selection is choosing the next action. If we elaborate a bit, while any number of actions is available not all choices are made equal. Depending on your current needs and goals, certain courses of action are more or less appropriate. So, action selection refers not only to the initiation of one course of action but also to the decision processes that lead to the initiation of (hopefully) the most appropriate course of action and the inhibition of others.

One way this could be achieved in the brain is to have a dedicated action selection module. To carry out the task of action selection successfully this module would require certain fundamental features. First, it would need access to neural representations of competing action choices i.e. receive input from a wide range of brain regions involved directly in motor control. Second, its output would need to have a direct influence on the expression of the winning movement, and inhibition of losing movements. Finally, to be able to make a decision on the most appropriate course of action the module would also need access to information about goals, motivations, context, internal drives (e.g. hunger, thirst) etc. in a form that would have direct influence over movement choice.

The basal ganglia and its anatomy

A candidate for one of the brains action selection modules is the basal ganglia. Which is? The basal ganglia is a group of interconnected nuclei* nestled deep below the bumpy outer casing of the cerebral cortex, more or less at the core of the brain. The four nuclei to keep in mind when it comes to action selection are the striatum, subthalamic nuclei (STN), globus pallidus (in particular the internal portion or GPi) and substantia nigra (a particular subregion called the substantia nigra pars reticulata or SNr is most important here).